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There are several options you can use to eliminate such artifacts.
Grid Resolution
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First, make sure your grid resolution is not too low. If you have a simulation with less than 10 milliоn voxels, the flickering might be resolved by increasing the grid resolution and simulating again.
Render-time Solutions
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There are also many ways to reduce or completely resolve such flickering after the simulation is done, without having to simulate all over again.
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